منابع مشابه
Oxygen free radicals and mitochondrial signaling in oligospermia and asthenospermia.
The aim of this study was to investigate the roles of oxygen free radicals and mitochondrial signaling in semen disorders, in particular, how this induces low concentrations and reduced motility of sperm. Ejaculate samples were obtained from 120 young adult males (mean age, 28.7±5.3 years) with normal semen (n=30), oligospermia (n=30), asthenospermia (n=30) and oligoasthenozoospermia (n=30). Th...
متن کاملOxygen radicals and signaling.
Recent evidence suggests that reactive oxygen species, such as superoxide anions and hydrogen peroxide, function as intracellular second messengers. This review will discuss the progress in understanding the intracellular pathways leading from ligand stimulation to the generation of oxidants, as well as some of the increasing number of cellular processes that appear to be subject to redox regul...
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BECLIN 1 is a central player in macroautophagy. AMBRA1, a BECLIN 1-interacting protein, positively regulates the BECLIN 1-dependent programme of autophagy. In this study, we show that AMBRA1 binds preferentially the mitochondrial pool of the antiapoptotic factor BCL-2, and that this interaction is disrupted following autophagy induction. Further, AMBRA1 can compete with both mitochondrial and e...
متن کاملOxygen Radicals and Related Species
As discussed in Chapter 1, around three billion years ago, life on Earth consisted of anaerobic microbes subsisting on the energy provided by cycles of electron transfer between prevalent populations of electron donors and acceptors. Potential donors were molecular hydrogen (H2), hydrogen sulfide (H2S) and methane (CH4), whose electrons were transferred to acceptors such as carbon dioxide (CO2)...
متن کاملOxygen radicals and asbestos carcinogenesis.
Asbestos fibers have been shown to generate reactive oxygen species using a variety of in vitro assays. It is hypothesized that these highly reactive metabolites mediate the development of malignant mesothelioma induced by asbestos fibers. DNA is a potential target of oxidant attack. Adaptive responses to oxidant injury have been described during exposure of mesothelial cells to asbestos fibers...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.42.29831